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Mucinex-Extended Release Bi-Layer Guaifenesin 600mg, 100 Tablets(Bonus Size) Mucinex Expectorant, 600 mg Guaifenesin Extended-Release Tablets helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive. Whenever you are congested, Mucinex can help.